bs-70254R

DATASHEET

Host: Rabbit

Target Protein: SARM1

Specificity: Specific for endogenous levels of the ~79 kDa SARM1 protein.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 23098

Swiss Prot: Q6SZW1

Source: Full length recombinant human SARM1 protein

Purification: Antigen Affinity purification from Pooled whole antiserum

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

NAD(+) hydrolase sterile alpha and TIR motif-containing protein 1 (SARM1), is the fifth member of the Toll/Il-1 Receptor (TIR) domain protein family. The highly conserved 724 amino acid protein is predominantly expressed in the brain, kidney and liver (Mink, M., et al 2001). Furthermore, SARM1 is enriched in the cytoplasm, mitchondria, and the axons, dendrites, and synapses of neurons (Panneerselvam, P., et al, 2012). SARM1 plays a key role in axonal degeneration by catalyzing the cleavage of NAD+ into ADPR, cADPR, and nicotinamide in response to injury triggering Wallerian degeneration (Gerdts, J. et al 2015). SARM1 has also been shown to activate neuronal cell death in response to stress (Peng, J. et al. 2010).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 79

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.