bs-70249R [Primary Antibody]
Ribosomal S6 kinase 2 Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Ribosomal S6 kinase 2

Specificity: Specific for endogenous levels of the ~90 kDa RSK2 protein.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 20112

Swiss Prot: Q9WUT3

Source: Synthetic peptide corresponding to amino acid residues from the C-terminal region on mouse ribosomal S6 kinase 2, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Antigen Affinity purification from Pooled whole antiserum

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

The p90 ribosomal S6 kinases (RSK)1–4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. The loss of RSK2 activity in humans leads to Coffin–Lowry syndrome, which is characterized by mental retardation and growth deficits (Hanauer and Young, 2002). Recent work suggests that RSK2 exerts a tonic regulation on G-protein coupled signaling (Sheffler et al., 2006).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 90


Cross Reactive Species: Human

Predicted Cross Reactive Species: Mouse
Rat
Dog
Bovine
Chicken

For research use only. Not intended for diagnostic or therapeutic use.