bs-70235R

DATASHEET

Host: Rabbit

Target Protein: PSD-95

Specificity: Specific for endogenous levels of the ~95 kDa PSD-95 protein.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 29495

Swiss Prot: P31016

Source: Synthetic peptide corresponding to amino acid residues from the N-terminal region of rat PSD-95, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Antigen Affinity purification from Pooled whole antiserum

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

PSD-95 is a very prominent component of the postsynaptic densities of synapses. It contains three PDZ domains which play key roles in its interactions with other proteins in the synapse. It has been proposed that these PDZ domains organize glutamate receptors and their associated signaling proteins and determine the size and strength of synapses (Kim and Sheng, 2004). Recent work suggests that interaction of the NMDAR with PSD-95 via these PDZ domains can be regulated by phosphorylation (Chung et al., 2004).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 95

Cross Reactive Species: Mouse
Rat

Predicted Cross Reactive Species: Human
Bovine
Zebrafish
Non-Human Primate

For research use only. Not intended for diagnostic or therapeutic use.