bs-70233R

DATASHEET

Host: Rabbit

Target Protein: Prosurfactant Protein C

Specificity: Specific for endogenous levels of the ~21 kDa Prosurfactant Protein C.

Clonality: Polyclonal

Isotype: IgG

Swiss Prot: P21841

Source: Synthetic peptide from the N-terminal region of mouse Prosurfactant Protein C.

Purification: Antigen Affinity purification

Storage Buffer: PBS

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Pulmonary surfactant Protein C (SP-C) is one of 4 distinct surfactant proteins; SP-A, SP-B, SP-C and SP-D. SP-C is produced by proteolytic cleavage of a larger precursor known as Prosurfactant Protein C which is expressed exclusively in the lungs and widely used as a marker for alveolar type 2 epithelial cells. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency and are associated with interstitial lung disease in older infants, children, and adults.

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 21

Cross Reactive Species: Mouse

Predicted Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.