bs-70223R

DATASHEET

Host: Rabbit

Target Protein: Phospholipase C β2 (PLC-β2)

Specificity: Specific for endogenous levels of PLC β2.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5330

Swiss Prot: Q00722

Source: Synthetic peptide corresponding to amino acid residues from the C-terminal region of human PLC β2.

Purification: Antigen Affinity purification from Pooled whole antiserum

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Phospholipases are quite common enzymes that are present in a broad range of organisms, including bacteria, yeast, plants, animals, and viruses. Phospholipase C (PLC) constitutes a class of enzymes that cleave phospholipids on the diacylglycerol (DAG) side of the phosphodiester bond (Cocco et al., 2015). A growing body of evidence supports the role of phospholipase C (PLC) in the invasion and metastasis of different tumors, including breast cancer (Bertagnolo et al., 2006). PLC-β2 has been shown to be required for sweet, umami and bitter taste perception in mammals (Zhang et al., 2003). Data also suggests that PLC-β2 serves an unappreciated role assembling components of the p38MAPK signaling module (Barr et al., 2002).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 135

Cross Reactive Species: Human
Non-Human Primate

For research use only. Not intended for diagnostic or therapeutic use.