bs-70222CH

DATASHEET

Host: Chicken

Target Protein: Peripherin

Specificity: Specific for endogenous levels of the ~57 kDa peripherin protein. This antibody performs well on aldehyde fixed tissues.

Clonality: Polyclonal

Isotype: IgY

Entrez Gene: 3414

Swiss Prot: P21807

Source: Recombinant rat peripherin expressed in and purified from E. coli.

Purification: Total IgY fraction

Storage Buffer: PBS + 10 mM NaN3.

Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliq

Background:

Peripherin is a ~57 kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury (1). Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors (2). Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes (3). Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration.

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 57

Cross Reactive Species: Human
Mouse
Rat
Bovine

Predicted Cross Reactive Species: Dog
Sheep
Horse
Cat
Rabbit
Guinea Pig
Goat
Hamster
Non-Human Primate

For research use only. Not intended for diagnostic or therapeutic use.