bs-70220R

DATASHEET

Host: Rabbit

Target Protein: Periostin pan

Specificity: Specific for endogenous levels of the three periostin bands around ~93 kDa. The immunogenic peptide is present in all known splice variants of periostin and therefore this antibody recognizes all known molecular forms of periostin. The antibody also works well for immunohistochemistry on paraformaldehyde-fixed sections with a simple antigen-retrieval protocol (incubate slides for 20 minutes at 90º C in 10 mM sodium citrate (pH6.0)/ 0.1 % Tween-20).

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 50706

Swiss Prot: Q62009

Source: Synthetic peptide corresponding to amino acid residues from the fasciclin domain 1 of mouse periostin.

Purification: Antigen Affinity purification

Storage Buffer: PBS

Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliq

Background:

Periostin is a matricellular protein, i.e. an extracellular matrix protein that interacts both with other ECM proteins and with cell-surface receptors. Like many other matricellular proteins, the function of periostin is important both in embryonic development and in the remodeling of adult tissues in response to pathological insults. Periostin was originally isolated as an osteoblast-specific marker that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading (Kruzynska-Frejtag A. et al., 2004). Periostin has recently been shown to promote collagen fibrogenesis, inhibit differentiation of progenitor cells into cardiomyocytes and to be essential in maintaining the biomechanical properties of the adult myocardium (Norris et al., 2008)

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 93

Cross Reactive Species: Human
Mouse
Rat
Chicken

Predicted Cross Reactive Species: Dog
Bovine
Sheep
Horse
Cat
Rabbit
Guinea Pig
Goat
Zebrafish
Fish
Hamster
Xenopus
Non-Human Primate
Vole
Finch

For research use only. Not intended for diagnostic or therapeutic use.