bs-70219R

DATASHEET

Host: Rabbit

Target Protein: Periostin C-terminal

Specificity: Specific for endogenous levels of the ~93 kDa periostin doublet. Consistent with the fact that this antibody is made against an alternatively spliced region of periostin, this antibody recognizes only the largest two of the three forms of periostin recognized on Western blots by the Pan periostin antibody (Cat. # 1622-PERI) and also shows a distinctive staining pattern by immunohistochemistry (data not shown).

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 50706

Swiss Prot: Q62009

Source: Bacterial fusion protein equivalent to a 188-amino acid polypeptide from the C-terminal region of mouse periostin which is comprised of six small alternatively-spliced exons.

Purification: Antigen Affinity purification

Storage Buffer: PBS

Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliq

Background:

Periostin is a matricellular protein, i.e. an extracellular matrix protein that interacts both with other ECM proteins and with cell-surface receptors. Like many other matricellular proteins, the function of periostin is important both in embryonic development and in the remodeling of adult tissues in response to pathological insults. Periostin was originally isolated as an osteoblast-specific marker that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading (Kruzynska-Frejtag A. et al., 2004). Periostin has since been demonstrated to be important in heart valve development and myocardial infarction because it promotes collagen fibrogenesis, inhibits differentiation of progenitor cells into cardiomyocytes and is essential in maintaining the biomechanical properties of the adult myocardium (Norris et al., 2008).

Size: 100ul

Concentration: Lot dependent

Predicted Molecular Weight: 93

Cross Reactive Species: Human
Mouse
Rat
Chicken

Predicted Cross Reactive Species: Dog
Bovine
Sheep
Horse
Cat
Rabbit
Guinea Pig
Goat
Hamster
Non-Human Primate
Vole
Finch

For research use only. Not intended for diagnostic or therapeutic use.