bs-70161R

DATASHEET

Host: Rabbit

Target Protein: Mitochondrial Fission Factor (MFF)

Specificity: Specific for endogenous levels of the ~38 kDa Mff protein.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 56947

Swiss Prot: Q9GZY8

Source: Human recombinant protein

Purification: Neat whole antiserum

Storage Buffer: Neat whole antiserum + 0.09% NaN3

Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliq

Background:

Mitochondrial fission factor, also known as Mff, is a tail-anchored, outer mitochondrial membrane protein that is part of a complex process controlling mitochondrial and peroxisomal fission in conjunction with Drp1 and Fis1 (Schrader and Yoon, 2007). The rate of mitochondrial fission and fusion balance each other for cell growth and survival of mitochondria. Fission can be greatly accelerated when cytochrome c is released during apoptosis (Desagher and Martinou, 2000). Mff was identified as an important component of the process through siRNA transfected cells, isolating the protein in the P2 pellet and demonstrating that Mff is exposed to the cytosol (Gandre-Babbe and van der Bliek 2008). Mff has been identified at different stages of the fission process working alongside, rather than in complex with, Fis1 suggesting that Mff contributes to fission independent of the Fis1 complex (Gandre-Babbe and van der Bliek 2008).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 38

Cross Reactive Species: Human
Mouse
Bovine

For research use only. Not intended for diagnostic or therapeutic use.