bs-70148CH

DATASHEET

Host: Chicken

Target Protein: MeCP2

Specificity: Specific for endogenous levels of the MeCP2 protein. Due to usually high charge, the protein runs at ~75 kDa in SDS-PAGE of mouse brain lysates.

Clonality: Polyclonal

Isotype: IgY

Entrez Gene: 4204

Swiss Prot: P51608

Source: Full length human recombinant MeCP2

Purification: Total IgY fraction

Storage Buffer: PBS + 5 mM NaN3.

Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliq

Background:

MeCP2 (Methyl-CpG Binding Protein 2) is a chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair and is not influenced by sequences flanking the methyl-CpGs. MeCP2 has been shown to mediate transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A (Nan et al., 1998). Defects in MeCP2 are the cause of Rett syndrome (RTT) (Amir et al., 1999). RTT is an X-linked dominant disease; it is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 75

Cross Reactive Species: Human
Mouse
Rat
Non-Human Primate

For research use only. Not intended for diagnostic or therapeutic use.