bs-70144CH

DATASHEET

Host: Chicken

Target Protein: MARCKS

Specificity: Specific for endogenous levels of the ~80 kDa MARCKS protein.

Clonality: Polyclonal

Isotype: IgY

Entrez Gene: 4082

Swiss Prot: P29966

Source: Recombinant human MARCKS expressed in and purified from E. coli

Purification: Total IgY fraction

Storage Buffer: PBS + 10 mM NaN3.

Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliq

Background:

Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) is a major substrate for phosphorylation by protein kinase C (PKC) (Ouimet et al.,1990) and is concentratedin synapses of neurons. It appears to function in synaptic vesicle cycling and has been shown to bind both actin and calmodulin in vitro (Hartwig et al. 1992). Deletion of the MARCKS gene in mice results in embryonic brain defects and death (Stumpo et al.1995). MARCKS is a member of a family of calmodulin binding proteins and phosphorylation of Ser-152/156 modulates the binding of MARCKS to calmodulin (Verghese et al., 1994).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 80

Cross Reactive Species: Human

Predicted Cross Reactive Species: Non-Human Primate

For research use only. Not intended for diagnostic or therapeutic use.