bs-70124R

DATASHEET

Host: Rabbit

Target Protein: GluR2/3

Specificity: Specific for endogenous levels of the ~100 kDa GluR2/3 protein.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 29627

Swiss Prot: P19491

Source: Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat GluR2/3, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Antigen Affinity purification from Pooled whole antiserum

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990;Hollmann and Heinemann, 1994). The GluR2 subunit is widely expressed throughout the nervous system where it is thought to play key roles in synaptic plasticity and learning and memory (Duprat et al., 2003;Seidenman et al., 2003;Chung et al., 2003;Yan et al., 2002).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 100

Cross Reactive Species: Rat

Predicted Cross Reactive Species: Human
Mouse
Chicken
Zebrafish

For research use only. Not intended for diagnostic or therapeutic use.