bs-70123R

DATASHEET

Host: Rabbit

Target Protein: GluR2

Specificity: Specific for endogenous levels of the ~100 kDa GluR2 protein.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 29627

Swiss Prot: P19491

Source: Synthetic peptide corresponding to amino acid residues specific to GluR2, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Antigen Affinity purification from Pooled whole antiserum

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990;Hollmann and Heinemann, 1994). The GluR2 subunit is thought to play a key role in forms of synaptic plasticity such as LTD (Chung et al., 2003).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 100

Cross Reactive Species: Rat

Predicted Cross Reactive Species: Human
Mouse
Chicken
Zebrafish
Non-Human Primate

For research use only. Not intended for diagnostic or therapeutic use.