bs-70115CH

DATASHEET

Host: Chicken

Target Protein: GAP43

Specificity: Specific for endogenous levels of the ~43 kDa GAP-43 protein.

Clonality: Polyclonal

Isotype: IgY

Entrez Gene: 29423

Swiss Prot: P07936

Source: Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat GAP43, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Total IgY fraction

Storage Buffer: PBS + 10 mM NaN3.

Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliq

Background:

GAP-43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration (Benowitz and Routtenberg, 1997). There is also evidence from knockout animals that GAP-43 serves to amplify pathfinding signals from the growth cone (Strittmatter et al., 1995). GAP-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser-41 by protein kinase C modulates the interaction of GAP-43 with actin (He et al., 1997) and may also affect neurotransmitter release during forms of plasticity like LTP (Hulo et al., 2002).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 43

Cross Reactive Species: Human
Mouse
Rat
Bovine
Horse

For research use only. Not intended for diagnostic or therapeutic use.