bs-70112R

DATASHEET

Host: Rabbit

Target Protein: GABAB Receptor (Ser923), R1-Subunit

Specificity: Specific for endogenous levels of the ~102 kDa GABAB R1 phosphorylated at Ser923. Immunolabeling is completely eliminated by treatment with λ-phosphatase.

Modification Site: Ser923

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 81657

Swiss Prot: Q9Z0U4

Source: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser923 of the R1-subunit of rat GABAB receptor, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Antigen Affinity purification from Pooled whole antiserum

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABA-A and the GABA-B subtype of receptors. GABA-B receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Phosphorylation enhances GABA-B receptor effector coupling (Couve et al., 2004). Phosphorylation of Ser-923 is thought to be important in the regulation of GABA-B receptor function.

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 102

Cross Reactive Species: Mouse
Rat

Predicted Cross Reactive Species: Human
Bovine
Non-Human Primate

For research use only. Not intended for diagnostic or therapeutic use.