bs-70093R

DATASHEET

Host: Rabbit

Target Protein: Fractin

Specificity: Specific for endogenous levels of the ~32 kDa fractin protein. Shows no reactivity toward intact actin. There is often a ladder of smaller bands in cells or culture or in vivo preparations due to further degradation by other proteases. In IHC the antibody detects the processes and cell bodies of degenerating neurons and plaque-associated microglia in Alzheimer's disease.

Clonality: Polyclonal

Isotype: IgG

Source: Synthetic peptide corresponding to amino acid residues from the C-terminal region of the 32 kDa actin fragment.

Purification: Neat whole antiserum

Storage Buffer: Neat whole antiserum

Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliq

Background:

Fractin (fragment of actin) is a caspase-specific cleavage product of actin and serves as a novel marker of apoptosis-related events. The antibody has been shown to detect the processes and cell bodies of degenerating neurons and plaque-associated microglia in Alzheimer’s disease (Yang et al., 1998). It has recently been reported that Fractin may have a functional role in apoptotic signaling in oligodendrocytes (Schulz, R., et al., Glia, 2009, in press).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 32

Cross Reactive Species: Human
Rat

For research use only. Not intended for diagnostic or therapeutic use.