bs-70078R

DATASHEET

Host: Rabbit

Target Protein: eIF4A2

Specificity: Specific for endogenous levels of the ~46 kDa eIF4A2 protein.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1917

Swiss Prot: Q14240

Source: Synthetic peptide from the N-terminal region of the human eIF4A2 protein.

Purification: Antigen Affinity purification from Pooled whole antiserum

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

The eIF4A, eukaryotic initiation factor 4A, are a set of proteins, eIF4A1, eIF4A2, and eIF4A3, that belong to the extensive DEAD-box RNA helicase family (Weinstein et al., 1997). They are involved in many aspects of RNA metabolism by virtue of their RNA-binding capacity and ATPase activity (Lu et al., 2014). eIF4A2 is a highly conserved gene for one of the protein-synthesis initiation factors involved in the binding of mRNA to the ribosome (Gingras et al., 1999). In humans eIF4A2 is expressed in all normal tissues, though highly expressed in skeletal muscle (Sudo et al., 1995). Studies suggest eIF4A2 may play a role in some cancers, specifically breast and lung cancer, along with melanoma (Shaoyan et al., 2013).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 46

Cross Reactive Species: Human
Mouse

Predicted Cross Reactive Species: Rat
Bovine
Non-Human Primate

For research use only. Not intended for diagnostic or therapeutic use.