bs-70070R

DATASHEET

Host: Rabbit

Target Protein: Dopamine Transporter, Extracellular Loop 2

Specificity: Specific for endogenous levels of the ~80 kDa DAT protein. Diffuse band may be observed between ~70-85 kDa due to variable glycosylation.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 6531

Swiss Prot: Q01959

Source: Synthetic peptide corresponding to amino acid residues from the extracellular loop 2 region of human dopamine transporter, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Antigen Affinity purification from Pooled whole antiserum

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

The dopamine transporter (DAT) is responsible for the reaccumulation of dopamine after it has been released. DAT antibodies and antibodies for other markers of catecholamine biosynthesis are widely used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). Levels of DAT protein expression are altered by chronic drug administration (Wilson et al., 1996).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 80

Cross Reactive Species: Human
Non-Human Primate

For research use only. Not intended for diagnostic or therapeutic use.