bs-70040R

DATASHEET

Host: Rabbit

Target Protein: ChAT

Specificity: Specific for endogenous levels of the ~70 kDa choline acetyltransferase protein.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1103

Swiss Prot: P28329.

Source: Native choline acetyltransferase purified from human placenta.

Purification: Neat whole antiserum

Storage Buffer: Neat whole antiserum

Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliq

Background:

Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer's disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 70

Cross Reactive Species: Human
Mouse
Rat
Chicken
Guinea Pig
Non-Human Primate

For research use only. Not intended for diagnostic or therapeutic use.