bs-70021CH

DATASHEET

Host: Chicken

Target Protein: Arginase I (ARG1)

Specificity: Specific for endogenous levels of the ~35-38 kDa arginase I protein.

Clonality: Polyclonal

Isotype: IgY

Entrez Gene: 29221

Swiss Prot: P07824

Source: Full-length recombinant rat liver arginase I expressed in and purified from E. Coli.

Purification: Total IgY fraction

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Arginase I, a cytosolic enzyme, is highly expressed in the liver and is a component of the urea cycle (Jenkinson et al, 1996). There are two isoforms of arginase, both catalyze the conversion of arginine to ornithine and urea, but differ based on subcellular localization, tissue distribution, and enzymatic properties (Jenkinson et al, 1996). Arginase I has been identified in macrophages in response to various pathogen exposures causing an upregulation of inducible nitric oxide synthase, iNOS, yielding increased levels of nitric oxide (Morris et al, 1998) and inflammation (Poljakovic et al, 2007).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 35/38

Cross Reactive Species: Human
Mouse
Rat
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.