bs-70014R

DATASHEET

Host: Rabbit

Target Protein: Alpha Synuclein (ser129)

Specificity: Specific for endogenous levels of the ~15 kDa alpha-synuclein protein phosphorylated at Ser129. Immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen, but not by the corresponding non-phosphopeptide.

Modification Site: Ser129

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 29219

Swiss Prot: P37377

Source: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser129 of rat alpha-aynuclein, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Antigen Affinity purification from Pooled whole antiserum

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alphasynuclein is one of the major components found in the Lewy bodies that occur in Parkinson’s disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Mutation of the alpha-synuclein gene is associated with familial forms of PD (Newmann et al., 2002). Recent evidence suggests that phosphorylation of alpha-synuclein at Ser129 plays a role in the formation of inclusions in PD (Smith et al., 2005; Masliah et al., 2005).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 15

Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Bovine
Non-Human Primate

For research use only. Not intended for diagnostic or therapeutic use.