bs-6994C
[Life Science]
LC3-mHTT-IN-AN1
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 411.04
Formula: C15 H9 Br2 N O3
CAS Number: 486443-73-6
InChi Key: GPKLWRHHVIBYEO-KMKOMSMNSA-N
InChi: InChI=1S/C15H9Br2NO3/c16-8-1-2-12-9(6-8)10(15(21)18-12)3-7-4-11(17)14(20)13(19)5-7/h1-6,19-20H,(H,18,21)/b10-3-
Smiles: OC1=CC(/C=C2\C(=O)NC3=CC=C(Br)C=C3\2)=CC(Br)=C1O
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C15 H9 Br2 N O3
CAS Number: 486443-73-6
InChi Key: GPKLWRHHVIBYEO-KMKOMSMNSA-N
InChi: InChI=1S/C15H9Br2NO3/c16-8-1-2-12-9(6-8)10(15(21)18-12)3-7-4-11(17)14(20)13(19)5-7/h1-6,19-20H,(H,18,21)/b10-3-
Smiles: OC1=CC(/C=C2\C(=O)NC3=CC=C(Br)C=C3\2)=CC(Br)=C1O
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
LC3-mHTT-IN-AN1 is a HTT-LC3 linker compound. LC3-mHTT-IN-AN1 interacts with both LC3 and mHTT, but not with the wild-type HTT protein. LC3-mHTT-IN-AN1 reduced mHTT levels in an allele-selective manner, and rescued disease-relevant phenotypes in cells and in vivo in fly and mouse models of Huntington's disease
Size: 10mg solid, 2mg solid 10mg solid, 2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.