DATASHEET
Formulation
Powder
Storage:
Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 532.56
Formula: C29 H27 F3 N6 O
CAS Number: 943319-70-8
InChi Key: PHXJVRSECIGDHY-UHFFFAOYSA-N
InChi: InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)
Smiles: CN1CCN(CC2=CC=C(C=C2C(F)(F)F)NC(=O)C2=CC=C(C)C(=C2)C#CC2=CN=C3C=CC=NN23)CC1
Purity: 98.0
Solubility: DMSO: 30 mg/mL(56.33 mM).
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
Ponatinib is an orally bioavailable multitargeted receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities. Multitargeted tyrosine kinase inhibitor AP24534 inhibits unmutated and all mutated forms of Bcr-Abl, including T315I, the highly drug therapy-resistant missense mutation of Bcr-Abl. This agent also inhibits other tyrosine kinases including those associated with vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs); in addition, it inhibits the tyrosine kinase receptor TIE2 and FMS-related tyrosine kinase receptor-3 (Flt3).