bs-6956C
[Life Science]
DK419
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 407.7
Formula: C16 H8 Cl F6 N3 O
CAS Number: 2102672-22-8
InChi Key: MWNNIGRGNSXNEA-UHFFFAOYSA-N
InChi: InChI=1S/C16H8ClF6N3O/c17-8-5-10(12-11(6-8)25-14(26-12)16(21,22)23)13(27)24-9-3-1-7(2-4-9)15(18,19)20/h1-6H,(H,24,27)(H,25,26)
Smiles: O=C(NC1C=CC(=CC=1)C(F)(F)F)C1=CC(Cl)=CC2NC(=NC=21)C(F)(F)F
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C16 H8 Cl F6 N3 O
CAS Number: 2102672-22-8
InChi Key: MWNNIGRGNSXNEA-UHFFFAOYSA-N
InChi: InChI=1S/C16H8ClF6N3O/c17-8-5-10(12-11(6-8)25-14(26-12)16(21,22)23)13(27)24-9-3-1-7(2-4-9)15(18,19)20/h1-6H,(H,24,27)(H,25,26)
Smiles: O=C(NC1C=CC(=CC=1)C(F)(F)F)C1=CC(Cl)=CC2NC(=NC=21)C(F)(F)F
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
DK419 is a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. DK419 inhibited Wnt/β-catenin signaling, altered cellular oxygen consumption rate and induced production of pAMPK. DK419 inhibited the growth of CRC tumor cells in vitro, had good plasma exposure when dosed orally, and inhibited the growth of patient derived CRC240 tumor explants in mice dosed orally.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.