bs-6874C
[Life Science]
GSK-25
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 513.33
Formula: C24 H16 Cl2 F2 N6 O
CAS Number: 874119-56-9
InChi Key: KZYAHEIPPAPADQ-UHFFFAOYSA-N
InChi: InChI=1S/C24H16Cl2F2N6O/c1-11-21(24(35)32-19-6-13-10-30-34-18(13)9-17(19)28)22(15-3-2-14(25)8-16(15)27)33-23(31-11)12-4-5-29-20(26)7-12/h2-10,22H,1H3,(H,30,34)(H,31,33)(H,32,35)
Smiles: CC1NC(=NC(C=1C(=O)NC1C=C2C=NNC2=CC=1F)C1C=CC(Cl)=CC=1F)C1=CC(Cl)=NC=C1
Purity: 98.0
Solubility: DMSO: 100 mg/mL (194.81 mM)
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C24 H16 Cl2 F2 N6 O
CAS Number: 874119-56-9
InChi Key: KZYAHEIPPAPADQ-UHFFFAOYSA-N
InChi: InChI=1S/C24H16Cl2F2N6O/c1-11-21(24(35)32-19-6-13-10-30-34-18(13)9-17(19)28)22(15-3-2-14(25)8-16(15)27)33-23(31-11)12-4-5-29-20(26)7-12/h2-10,22H,1H3,(H,30,34)(H,31,33)(H,32,35)
Smiles: CC1NC(=NC(C=1C(=O)NC1C=C2C=NNC2=CC=1F)C1C=CC(Cl)=CC=1F)C1=CC(Cl)=NC=C1
Purity: 98.0
Solubility: DMSO: 100 mg/mL (194.81 mM)
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
GSK-25 is a potent, selective and orally bioavailable ROCK1 inhibitor (IC50=7 nM). GSK-25 maintains good selectivity against a panel of 31 kinases (>100 fold), as well as RSK1 and p70S6K (RSK1: IC50=398 nM, p70S6K: IC50=1 μM). GSK-25 inhibits P450 profile (IC50s of 2.5, 5.2, 2.5 µM for CYP2C9, CYP2D6, CYP3A4, respectively).
Size: 10mg solid, 2mg solid 10mg solid, 2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.