bs-6796C
[Life Science]
Mitoxantrone dihydrochloride
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 517.4
Formula: C22 H30 Cl2 N4 O6
CAS Number: 70476-82-3
InChi Key: ZAHQPTJLOCWVPG-UHFFFAOYSA-N
InChi: InChI=1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
Smiles: Cl.Cl.OC1=CC=C(O)C2=C1C(=O)C1C(=C(C=CC=1NCCNCCO)NCCNCCO)C2=O
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C22 H30 Cl2 N4 O6
CAS Number: 70476-82-3
InChi Key: ZAHQPTJLOCWVPG-UHFFFAOYSA-N
InChi: InChI=1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
Smiles: Cl.Cl.OC1=CC=C(O)C2=C1C(=O)C1C(=C(C=CC=1NCCNCCO)NCCNCCO)C2=O
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
Mitoxantrone is an anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC50 = 5.3 μM), thus inhibiting cell proliferation. It also inhibits HIV-1 integrase (IC50 = 3.8 μM). Mitoxantrone is exported from cells in an ATP- and glutathione-dependent manner by multidrug resistance protein-1.4 Formulations containing mitoxantrone have been used in the treatment of cancer and multiple sclerosis.
Size: 10mg solid, 2mg solid 10mg solid, 2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.