bs-6789C
[Life Science]
Rottlerin
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 516.54
Formula: C30 H28 O8
CAS Number: 82-08-6
InChi Key: DEZFNHCVIZBHBI-ZHACJKMWSA-N
InChi: InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+
Smiles: CC(=O)C1C(O)=C(CC2C(O)=C(C3OC(C)(C)C=CC=3C=2O)C(=O)/C=C/C2C=CC=CC=2)C(O)=C(C)C=1O
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C30 H28 O8
CAS Number: 82-08-6
InChi Key: DEZFNHCVIZBHBI-ZHACJKMWSA-N
InChi: InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+
Smiles: CC(=O)C1C(O)=C(CC2C(O)=C(C3OC(C)(C)C=CC=3C=2O)C(=O)/C=C/C2C=CC=CC=2)C(O)=C(C)C=1O
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
Rottlerin is an angiogenesis inhibitor and an inhibitor of protein kinase Cdelta (PKCdelta) and calmodulin kinase III. Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma. Rottlerin induces cyclooxygenase-2 upregulation through an ATF4 and reactive oxygen species-independent pathway in HEI-OC1 cells. Rottlerin exerts its anti-tumor activity through inhibition of Skp2 in breast cancer cells. Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.