bs-6788C

DATASHEET

Formulation Powder

Storage: Store in dry, dark place at -20C for 1 year.

Product Information:

Molecular Weight: 438.48

Formula: C25 H22 N6 O2

CAS Number: 425637-18-9

InChi Key: OAVGBZOFDPFGPJ-UHFFFAOYSA-N

InChi: InChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)

Smiles: CN1CCN(CC1)C1=NC2=CC=CC=C2C(=N1)C1=C(C2=CNC3=CC=CC=C23)C(=O)NC1=O

Purity: 98.0

Solubility: Soluble in DMSO, not in water

Appearance: Solid Power.

Shelf Life: 1.0 years

Description:

Sotrastaurin, also known as AEB-071, is an orally available pan-protein kinase C (PKC) inhibitor with potential immunosuppressive and antineoplastic activities. Sotrastaurin inhibits both T- and B-cell activations via PKC theta and beta isozymes, respectively. Both PKCs are important in the activation of nuclear factor-kappaB (NF-kB). Inhibition of PKC beta in B-cells results in prevention of NF-kB-mediated signaling and down regulation of NF-kB target genes. This may eventually lead to an induction of G1 cell cycle arrest and tumor cell apoptosis in susceptible tumor cells. This agent may act synergistically with other chemotherapeutic agents.