bs-6719C
[Life Science]
PLX-4720
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 413.83
Formula: C17 H14 Cl F2 N3 O3 S
CAS Number: 918505-84-7
InChi Key: YZDJQTHVDDOVHR-UHFFFAOYSA-N
InChi: InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22)
Smiles: CCCS(=O)(=O)NC1C=CC(F)=C(C(=O)C2=CNC3=NC=C(Cl)C=C23)C=1F
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C17 H14 Cl F2 N3 O3 S
CAS Number: 918505-84-7
InChi Key: YZDJQTHVDDOVHR-UHFFFAOYSA-N
InChi: InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22)
Smiles: CCCS(=O)(=O)NC1C=CC(F)=C(C(=O)C2=CNC3=NC=C(Cl)C=C23)C=1F
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
PLX-4720 is a 7-azaindole derivative that inhibits B-Raf(V600E) with an IC(50) of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PLX-4720 preferentially inhibits the active B-Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.