bs-6713C
[Life Science]
TAS-116
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 454.53
Formula: C25 H26 N8 O
CAS Number: 1260533-36-5
InChi Key: JMNDKGSFCHWKBP-UHFFFAOYSA-N
InChi: InChI=1S/C25H26N8O/c1-5-26-25(34)17-6-8-19(9-7-17)33-24-22(23(30-33)16(2)3)21(10-11-27-24)32-14-20(28-15-32)18-12-29-31(4)13-18/h6-16H,5H2,1-4H3,(H,26,34)
Smiles: CN1C=C(C=N1)C1=CN(C=N1)C1C=CN=C2C=1C(=NN2C1C=CC(=CC=1)C(=O)NCC)C(C)C
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C25 H26 N8 O
CAS Number: 1260533-36-5
InChi Key: JMNDKGSFCHWKBP-UHFFFAOYSA-N
InChi: InChI=1S/C25H26N8O/c1-5-26-25(34)17-6-8-19(9-7-17)33-24-22(23(30-33)16(2)3)21(10-11-27-24)32-14-20(28-15-32)18-12-29-31(4)13-18/h6-16H,5H2,1-4H3,(H,26,34)
Smiles: CN1C=C(C=N1)C1=CN(C=N1)C1C=CN=C2C=1C(=NN2C1C=CC(=CC=1)C(=O)NCC)C(C)C
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
TAS-116, also known as Pimitespib, is a potent and selective inhibitor of heat shock protein 90 (Hsp90) subtypes alpha and beta, with potential antineoplastic and chemo/radiosensitizing activities. TAS-116 specifically binds to and inhibits the activity of Hsp90 alpha and beta; this results in the proteasomal degradation of oncogenic client proteins, which inhibits client protein dependent-signaling, induces apoptosis, and inhibits the proliferation of cells overexpressing HSP90alpha/beta.
Size: 10mg solid, 2mg solid 10mg solid, 2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.