bs-6708C
[Life Science]
AKT-IN-VIII
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 551.64
Formula: C34 H29 N7 O
CAS Number: 612847-09-3
InChi Key: BIWGYFZAEWGBAL-UHFFFAOYSA-N
InChi: InChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25H,14-17,20H2,(H,35,36)(H,39,42)
Smiles: O=C1NC2C=CC=CC=2N1C1CCN(CC2C=CC(=CC=2)C2N=C3C=C4NC=NC4=CC3=NC=2C2C=CC=CC=2)CC1
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C34 H29 N7 O
CAS Number: 612847-09-3
InChi Key: BIWGYFZAEWGBAL-UHFFFAOYSA-N
InChi: InChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25H,14-17,20H2,(H,35,36)(H,39,42)
Smiles: O=C1NC2C=CC=CC=2N1C1CCN(CC2C=CC(=CC=2)C2N=C3C=C4NC=NC4=CC3=NC=2C2C=CC=CC=2)CC1
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
AKT-IN-VIII, also known as AKTi-1/2, is a potent, selective and ell permeable, allosteric inhibitor of Akt 1 and 2, which efficiently inhibits CaMKIα activity and aryl hydrocarbon receptor pathway. AKT-IN-VIII suppresses hyperthermia-induced Ndrg2 phosphorylation in gastric cancer cells. AKT-IN-VIII displays good selectivity against a panel of 70 other kinases with micromolar inhibition against some kinases, for example, calcium/calmodulin-dependent protein kinase 1 and smooth muscle myosin light-chain kinase.
Size: 10mg solid, 2mg solid 10mg solid, 2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.