bs-6684C
[Life Science]
NSC59984
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 265.27
Formula: C12 H15 N3 O4
CAS Number: 803647-40-7
InChi Key: QKTRIGNWBRHBFV-DUXPYHPUSA-N
InChi: InChI=1S/C12H15N3O4/c1-13-6-8-14(9-7-13)11(16)4-2-10-3-5-12(19-10)15(17)18/h2-5H,6-9H2,1H3/b4-2+
Smiles: CN1CCN(CC1)C(=O)/C=C/C1=CC=C(O1)[N+]([O-])=O
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C12 H15 N3 O4
CAS Number: 803647-40-7
InChi Key: QKTRIGNWBRHBFV-DUXPYHPUSA-N
InChi: InChI=1S/C12H15N3O4/c1-13-6-8-14(9-7-13)11(16)4-2-10-3-5-12(19-10)15(17)18/h2-5H,6-9H2,1H3/b4-2+
Smiles: CN1CCN(CC1)C(=O)/C=C/C1=CC=C(O1)[N+]([O-])=O
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
NSC59984 is a p53 pathway activator. NSC59984 restores wild-type p53 signaling via p73 activation, specifically in mutant p53-expressing colorectal cancer cells. NSC59984 synergizes with CPT11 to induce cell death in mutant p53-expressing colorectal cancer cells and inhibits mutant p53-associated colon tumor xenograft growth in a p73-dependent manner in vivo. NSC59984 as a promising lead compound for anticancer therapy that acts by targeting GOF-mutant p53 and stimulates p73 to restore the p53 pathway signaling.
Size: 10mg solid, 2mg solid 10mg solid, 2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.