bs-6665C
[Life Science]
LY-303511
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 306.36
Formula: C19 H18 N2 O2
CAS Number: 154447-38-8
InChi Key: NGAGMBNBKCDCDJ-UHFFFAOYSA-N
InChi: InChI=1S/C19H18N2O2/c22-17-13-18(21-11-9-20-10-12-21)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13,20H,9-12H2
Smiles: O=C1C=C(OC2C(=CC=CC=21)C1C=CC=CC=1)N1CCNCC1
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C19 H18 N2 O2
CAS Number: 154447-38-8
InChi Key: NGAGMBNBKCDCDJ-UHFFFAOYSA-N
InChi: InChI=1S/C19H18N2O2/c22-17-13-18(21-11-9-20-10-12-21)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13,20H,9-12H2
Smiles: O=C1C=C(OC2C(=CC=CC=21)C1C=CC=CC=1)N1CCNCC1
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
LY-303511, also known as NV-128 and EM 101, is a potent mTOR inhibitor. LY-303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. LY-303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization. LY-303511 acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.