bs-6633C
[Life Science]
Torin 1
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 607.62
Formula: C35 H28 F3 N5 O2
CAS Number: 1222998-36-8
InChi Key: AKCRNFFTGXBONI-UHFFFAOYSA-N
InChi: InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3
Smiles: CCC(=O)N1CCN(CC1)C1C=CC(=CC=1C(F)(F)F)N1C2=C(C=CC1=O)C=NC1C=CC(=CC=12)C1=CC2=CC=CC=C2N=C1
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C35 H28 F3 N5 O2
CAS Number: 1222998-36-8
InChi Key: AKCRNFFTGXBONI-UHFFFAOYSA-N
InChi: InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3
Smiles: CCC(=O)N1CCN(CC1)C1C=CC(=CC=1C(F)(F)F)N1C2=C(C=CC1=O)C=NC1C=CC(=CC=12)C1=CC2=CC=CC=C2N=C1
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
Torin-1 is a potent and selective mTOR inhibitor. The apoptosis-inducing mTOR inhibitor Torin-1 hindered growth, motility, invasion, and survival of CoCSCs in vitro, and suppressed tumor growth in vivo with a concomitant reduction in vessel formation. Torin-1 also affected the expression of markers for cell proliferation, angio-/lympho-genesis, and stemness in vivo, including Ki67, DLL1, DLL4, Notch, Lgr5, and CD44. Importantly, Torin-1 did not affect the survival of normal colon stem cells in vivo, suggesting its selectivity towards cancer cells.
Size: 10mg solid, 2mg solid 10mg solid, 2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.