bs-6619C
[Life Science]
AL 082D06
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 409.91
Formula: C23 H24 Cl N3 O2
CAS Number: 256925-03-8
InChi Key: IPICUXHYPAMJNC-UHFFFAOYSA-N
InChi: InChI=1S/C23H24ClN3O2/c1-25(2)18-9-5-16(6-10-18)23(17-7-11-19(12-8-17)26(3)4)21-15-20(27(28)29)13-14-22(21)24/h5-15,23H,1-4H3
Smiles: CN(C)C1C=CC(=CC=1)C(C1C=C(C=CC=1Cl)[N+]([O-])=O)C1C=CC(=CC=1)N(C)C
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C23 H24 Cl N3 O2
CAS Number: 256925-03-8
InChi Key: IPICUXHYPAMJNC-UHFFFAOYSA-N
InChi: InChI=1S/C23H24ClN3O2/c1-25(2)18-9-5-16(6-10-18)23(17-7-11-19(12-8-17)26(3)4)21-15-20(27(28)29)13-14-22(21)24/h5-15,23H,1-4H3
Smiles: CN(C)C1C=CC(=CC=1)C(C1C=C(C=CC=1Cl)[N+]([O-])=O)C1C=CC(=CC=1)N(C)C
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
AL082D06, also known as D-06, is a nonsteroidal glucocorticoid receptor antagonist. AL082D06 binds specifically to GR with no measurable binding affinity to the progesterone receptor. AL082D06 binds with nanomolar affinity to the GR and has no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins. AL082D06 inhibits glucocorticoid-mediated transcriptional regulation. AL082D06 binds competitively with steroids, likely occupying a similar site within the ligand-binding domain.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.