bs-66055C
[Life Science]
Purmorphamine, Hedgehog Agonist
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 520.62
Formula: C31 H32 N6 O2
CAS Number: 483367-10-8
InChi Key: FYBHCRQFSFYWPY-UHFFFAOYSA-N
InChi: InChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)
Smiles: C1COCCN1C1C=CC(=CC=1)NC1N=C(N=C2C=1N=CN2C1CCCCC1)OC1=CC=CC2=CC=CC=C21
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C31 H32 N6 O2
CAS Number: 483367-10-8
InChi Key: FYBHCRQFSFYWPY-UHFFFAOYSA-N
InChi: InChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)
Smiles: C1COCCN1C1C=CC(=CC=1)NC1N=C(N=C2C=1N=CN2C1CCCCC1)OC1=CC=CC2=CC=CC=C21
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
Purmorphamine is a Hedgehog agonist, which activates the Hedgehog pathway by targeting Smoothened. Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Purmorphamine increases DARPP-32 differentiation in human striatal neural stem cells through the Hedgehog pathway. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Hedgehog (Hh) signaling is an important regulator of embryonic patterning, tissue regeneration, stem cell renewal and cancer growth.
Size: 5 mg solid,10 mg solid, 10 mM in DMSO (0.96 5 mg solid,10 mg solid, 10 mM in DMSO (0.962 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.