bs-66054C
[Life Science]
IOX2, HIF Prolyl-Hydroxylases (PHD2) Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 352.34
Formula: C19 H16 N2 O5
CAS Number: 931398-72-0
InChi Key: CAOSCCRYLYQBES-UHFFFAOYSA-N
InChi: InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)
Smiles: OC(=O)CNC(=O)C1C(=O)N(CC2C=CC=CC=2)C2=CC=CC=C2C=1O
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C19 H16 N2 O5
CAS Number: 931398-72-0
InChi Key: CAOSCCRYLYQBES-UHFFFAOYSA-N
InChi: InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)
Smiles: OC(=O)CNC(=O)C1C(=O)N(CC2C=CC=CC=2)C2=CC=CC=C2C=1O
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
IOX2 is a potent, selective and cell permeable inhibitor of hypoxia inducible factor 1α (HIF1α) prolyl hydroxylase-2 (PHD2). It inhibits PHD2 with an IC50 ~21 nM, and exhibits over 100-fold selectivity against JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH. IOX2 is active in cells, inhibiting HIF-1α hydroxylation in RCC4 cells at 50 μM.
Size: 10 mg solid , 2mg solid ,10 mM in DMSO (0.5 10 mg solid , 2mg solid ,10 mM in DMSO (0.568 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.