bs-66046C
[Life Science]
MI-2, Menin-MLL Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 375.55
Formula: C18 H25 N5 S2
CAS Number: 1271738-62-5
InChi Key: SRQYLNYQAPCPIR-UHFFFAOYSA-N
InChi: InChI=1S/C18H25N5S2/c1-4-5-13-10-14-15(20-12-21-16(14)24-13)22-6-8-23(9-7-22)17-19-11-18(2,3)25-17/h10,12H,4-9,11H2,1-3H3
Smiles: CCCC1=CC2C(=NC=NC=2S1)N1CCN(CC1)C1=NCC(C)(C)S1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C18 H25 N5 S2
CAS Number: 1271738-62-5
InChi Key: SRQYLNYQAPCPIR-UHFFFAOYSA-N
InChi: InChI=1S/C18H25N5S2/c1-4-5-13-10-14-15(20-12-21-16(14)24-13)22-6-8-23(9-7-22)17-19-11-18(2,3)25-17/h10,12H,4-9,11H2,1-3H3
Smiles: CCCC1=CC2C(=NC=NC=2S1)N1CCN(CC1)C1=NCC(C)(C)S1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
MI-2 is a potent and specific Menin-MLL inhibitor with an IC50 ~446 nM. It specifically binds to Menin and inhibits Menin’s interaction with MLL fusion proteins in cells. It can effectively reverse MLL fusion protein–mediated leukemic transformation by downregulating the expression of target genes downstream of MLL fusion protein oncogenic activity. MI-2 is a new tool for better understanding MLL-mediated leukemogenesis and represents a new approach for studying the role of Menin as an oncogenic cofactor of MLL fusion proteins.
Size: 10mg solid, 2mg solid ,10 mM in DMSO (0.533 10mg solid, 2mg solid ,10 mM in DMSO (0.533 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.