bs-66044C
[Life Science]
KL001, Cryptochrome Activator
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 398.48
Formula: C21 H22 N2 O4 S
CAS Number: 309928-48-1
InChi Key: OQAFDLPAPSSOHY-UHFFFAOYSA-N
InChi: InChI=1S/C21H22N2O4S/c1-28(25,26)22(15-17-7-6-12-27-17)13-16(24)14-23-20-10-4-2-8-18(20)19-9-3-5-11-21(19)23/h2-12,16,24H,13-15H2,1H3
Smiles: CS(=O)(=O)N(CC(O)CN1C2=CC=CC=C2C2C=CC=CC1=2)CC1=CC=CO1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C21 H22 N2 O4 S
CAS Number: 309928-48-1
InChi Key: OQAFDLPAPSSOHY-UHFFFAOYSA-N
InChi: InChI=1S/C21H22N2O4S/c1-28(25,26)22(15-17-7-6-12-27-17)13-16(24)14-23-20-10-4-2-8-18(20)19-9-3-5-11-21(19)23/h2-12,16,24H,13-15H2,1H3
Smiles: CS(=O)(=O)N(CC(O)CN1C2=CC=CC=C2C2C=CC=CC1=2)CC1=CC=CO1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
KL001 is a novel and specific small molecule activator of cryptochrome (CRY) identified from an unbiased cell-based circadian screen (in human osteosarcoma U2OS cell line harboring a Bmal1-dLuc luciferase reporter). KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. In addition, KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. Therefore, KL001 serves as a useful tool to study the regulation of CRY-dependent physiology and may help development of clock-based therapeutics for treating diabetes.
Size: 10mg solid, 2mg solid , 10 mM in DMSO (0.50310mg solid, 2mg solid , 10 mM in DMSO (0.503 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.