bs-6569C
[Life Science]
KN-62
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 721.84
Formula: C38 H35 N5 O6 S2
CAS Number: 127191-97-3
InChi Key: RJVLFQBBRSMWHX-DHUJRADRSA-N
InChi: InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1
Smiles: CN([C@@H](CC1C=CC(=CC=1)OS(=O)(=O)C1=CC=CC2=CN=CC=C12)C(=O)N1CCN(CC1)C1C=CC=CC=1)S(=O)(=O)C1=CC=CC2=CN=CC=C12
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C38 H35 N5 O6 S2
CAS Number: 127191-97-3
InChi Key: RJVLFQBBRSMWHX-DHUJRADRSA-N
InChi: InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1
Smiles: CN([C@@H](CC1C=CC(=CC=1)OS(=O)(=O)C1=CC=CC2=CN=CC=C12)C(=O)N1CCN(CC1)C1C=CC=CC=1)S(=O)(=O)C1=CC=CC2=CN=CC=C12
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
KN62 is a P2X7R antagonist (hP2X7 IC50 = 51 nM) and Ca2+/calmodulin-dependent protein kinase II inhibitor. KN62 inhibits the invasiveness of cancer cells in vitro and in vivo KN62 causes retrograde amnesia in the rat. KN62 attenuates glutamate release by inhibiting voltage-dependent Ca(2+)-channels. The effect of KN62 on Ca(2+)-influx appears to be specific to slowly-or non-inactivating conductances, and therefore presents KN62 as a potentially useful tool.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.