bs-6557C
[Life Science]
ML364
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 517.54
Formula: C24 H18 F3 N3 O3 S2
CAS Number: 1991986-30-1
InChi Key: QZUGMNXETPARLI-UHFFFAOYSA-N
InChi: InChI=1S/C24H18F3N3O3S2/c1-15-7-10-18(11-8-15)35(32,33)30-20-13-17(24(25,26)27)9-12-19(20)22(31)29-23-28-21(14-34-23)16-5-3-2-4-6-16/h2-14,30H,1H3,(H,28,29,31)
Smiles: CC1C=CC(=CC=1)S(=O)(=O)NC1C=C(C=CC=1C(=O)NC1=NC(=CS1)C1=CC=CC=C1)C(F)(F)F
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C24 H18 F3 N3 O3 S2
CAS Number: 1991986-30-1
InChi Key: QZUGMNXETPARLI-UHFFFAOYSA-N
InChi: InChI=1S/C24H18F3N3O3S2/c1-15-7-10-18(11-8-15)35(32,33)30-20-13-17(24(25,26)27)9-12-19(20)22(31)29-23-28-21(14-34-23)16-5-3-2-4-6-16/h2-14,30H,1H3,(H,28,29,31)
Smiles: CC1C=CC(=CC=1)S(=O)(=O)NC1C=C(C=CC=1C(=O)NC1=NC(=CS1)C1=CC=CC=C1)C(F)(F)F
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
ML364 is a small molecule inhibitor of the deubiquitinase USP2 with potential anticancer activity. ML364 has an IC50 of 1.1 μm in a biochemical assay using an internally quenched fluorescent di-ubiquitin substrate. Direct binding of ML364 to USP2 was demonstrated using microscale thermophoresis. ML364 induced an increase in cellular cyclin D1 degradation and caused cell cycle arrest as shown in Western blottings and flow cytometry assays utilizing both Mino and HCT116 cancer cell lines.
Size: 10mg solid, 2mg solid 10mg solid, 2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.