bs-6556C
[Life Science]
AG-120
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 582.96
Formula: C28 H22 Cl F3 N6 O3
CAS Number: 1448346-63-1
InChi Key: WIJZXSAJMHAVGX-XADRRFQNSA-N
InChi: InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25?/m0/s1
Smiles: N#CC1C=CN=C(C=1)N1[C@@H](CCC1=O)C(=O)N(C(C1C=CC=CC=1Cl)C(=O)NC1CC(F)(F)C1)C1=CC(F)=CN=C1
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C28 H22 Cl F3 N6 O3
CAS Number: 1448346-63-1
InChi Key: WIJZXSAJMHAVGX-XADRRFQNSA-N
InChi: InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25?/m0/s1
Smiles: N#CC1C=CN=C(C=1)N1[C@@H](CCC1=O)C(=O)N(C(C1C=CC=CC=1Cl)C(=O)NC1CC(F)(F)C1)C1=CC(F)=CN=C1
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
AG-120 (racemic), a racemic mixture of AG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Upon administration, AG-120 specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells.
Size: 10mg solid, 2mg solid 10mg solid, 2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.