bs-6555C

DATASHEET

Formulation Powder

Storage: Store in dry, dark place at -20C for 1 year.

Product Information:

Molecular Weight: 396.44

Formula: C23 H20 N6 O

CAS Number: 726169-73-9

InChi Key: HRNLUBSXIHFDHP-UHFFFAOYSA-N

InChi: InChI=1S/C23H20N6O/c24-19-5-1-2-6-21(19)28-22(30)17-9-7-16(8-10-17)14-27-23-26-13-11-20(29-23)18-4-3-12-25-15-18/h1-13,15H,14,24H2,(H,28,30)(H,26,27,29)

Smiles: NC1C=CC=CC=1NC(=O)C1C=CC(CNC2N=C(C=CN=2)C2=CC=CN=C2)=CC=1

Purity: 98.0

Solubility: DMSO: 13 mg/mL(32.79 mM).

Appearance: Solid Power

Shelf Life: 1.0 years

Description:

MGCD0103, also known as Mocetinostat, is a rationally designed, orally available, Class 1-selective, small molecule, 2-aminobenzamide HDAC inhibitor with potential antineoplastic activity. MGCD0103 binds to and inhibits Class 1 isoforms of HDAC, specifically HDAC 1, 2 and 3, which may result in epigenetic changes in tumor cells and so tumor cell death; although the exact mechanism has yet to be defined, tumor cell death may occur through the induction of apoptosis, differentiation, cell cycle arrest, inhibition of DNA repair, upregulation of tumor suppressors, down regulation of growth factors, oxidative stress, and autophagy, among others.