bs-6553C
[Life Science]
PF-670462 2HCl
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 410.32
Formula: C19 H22 Cl2 F N5
CAS Number: 950912-80-8
InChi Key: PSNKGVAXBSAHCH-UHFFFAOYSA-N
InChi: InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H
Smiles: Cl.Cl.NC1N=C(C=CN=1)C1=C(N=CN1C1CCCCC1)C1C=CC(F)=CC=1
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C19 H22 Cl2 F N5
CAS Number: 950912-80-8
InChi Key: PSNKGVAXBSAHCH-UHFFFAOYSA-N
InChi: InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H
Smiles: Cl.Cl.NC1N=C(C=CN=1)C1=C(N=CN1C1CCCCC1)C1C=CC(F)=CC=1
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
PF-670462 2HCl is a potent inhibitor of the CK1 isoforms CK1ε and CK1δ (IC50 = 7.7 and 14 nM, respectively). Inhibition of CKIepsilon yields a perturbation of oscillator function that forestalls light as a zeitgeber, and they demonstrate that pharmacological tools such as PF-670462 may yield valuable insight into clock function. Casein kinase Iepsilon (CKIepsilon) is an essential component of the biological clock, phosphorylating PER proteins, and in doing so regulating their turnover and nuclear entry in oscillator cells of the suprachiasmatic nucleus (SCN).
Size: 10mg solid, 2mg solid 10mg solid, 2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.