DATASHEET
Formulation
Powder
Storage:
Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 364.78
Formula: C17 H17 Cl N2 O5
CAS Number: 305834-79-1
InChi Key: DXVKFBGVVRSOLI-UHFFFAOYSA-N
InChi: InChI=1S/C17H17ClN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3
Smiles: CCOC(=O)C1C(C(C#N)C(=O)OCC)C2=CC(Cl)=CC=C2OC=1N
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
SC-79 is an activator of Akt that blocks its membrane translocation while allowing its phosphorylation, in the cytosol, by upstream kinases. SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head. SC-79 injections inhibited alcohol-induced osteonecrosis. Alcohol-induced ONFH is associated with suppression of p-Akt-Ser473 in the Akt/GSK3β/β-catenin signaling pathway in bone mesenchymal stem cells.