DATASHEET
Formulation
Powder
Storage:
Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 409.48
Formula: C23 H27 N3 O4
CAS Number: 1094042-01-9
InChi Key: NUIKTBLZSPQGCP-UHFFFAOYSA-N
InChi: InChI=1S/C23H27N3O4/c1-3-28-20-11-8-15(14-21(20)29-4-2)23-25-22(26-30-23)18-7-5-6-17-16(18)9-10-19(17)24-12-13-27/h5-8,11,14,19,24,27H,3-4,9-10,12-13H2,1-2H3
Smiles: CCOC1C=CC(=CC=1OCC)C1=NC(=NO1)C1C=CC=C2C(CCC=12)NCCO
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist. CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment. CYM-5442 significantly inhibited but did not prevent aGVHD. CYM-5442 treatment downregulated CCL2 and CCL7 expression in endothelial cells, therefore reducing the migration of monocytes, from which tissue macrophages originate. CYM-5442 may be a potential therapeutic regimen for aGVHD.