DATASHEET
Formulation
Powder
Storage:
Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 253.08
Formula: C12 H6 Cl2 O2
CAS Number: 79756-69-7
InChi Key: ZKHFYORNAYYOTM-UHFFFAOYSA-N
InChi: InChI=1S/C12H6Cl2O2/c13-7-1-3-11(14)9(5-7)10-6-8(15)2-4-12(10)16/h1-6H
Smiles: O=C1C=CC(=O)C=C1C1C=C(Cl)C=CC=1Cl
Purity: 98.0
Solubility: DMSO: 51 mg/mL(201.51 mM).
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor. TPI-1 selectively increased SHP-1 phospho-substrates (pLck-pY394, pZap70, and pSlp76) in Jurkat T cells but had little effects on pERK1/2 or pLck-pY505 regulated by phosphatases SHP-2 or CD45, respectively. TPI-1 induced mouse splenic-IFN-gamma(+) cells in vitro, approximately 58-fold more effective than sodium stibogluconate, and increased mouse splenic-pLck-pY394 and -IFN-gamma(+) cells in vivo.