bs-6542C

DATASHEET

Formulation Powder

Storage: Store in dry, dark place at -20C for 1 year.

Product Information:

Molecular Weight: 418.5

Formula: C26 H27 F N2 O2

CAS Number: 1174130-61-0

InChi Key: ZHPMYDSXGRRERG-DEOSSOPVSA-N

InChi: InChI=1S/C26H27FN2O2/c1-17-12-18(2)14-21(13-17)24-4-3-11-29(24)16-19-5-8-22(9-6-19)31-25-10-7-20(26(28)30)15-23(25)27/h5-10,12-15,24H,3-4,11,16H2,1-2H3,(H2,28,30)/t24-/m0/s1

Smiles: CC1=CC(=CC(C)=C1)[C@@H]1CCCN1CC1C=CC(=CC=1)OC1C=CC(=CC=1F)C(N)=O

Purity: 98.0

Solubility: Soluble in DMSO

Appearance: Solid Power

Shelf Life: 1.0 years

Description:

CERC-501, also known as JNJ-67953964, LY-2456302 and Aticaprant, is a potent, selective, short-acting antagonist of the κ-opioid receptor (KOR) (Ki = 0.81 nM vs. 24.0 nM and 155 nM for the μ-opioid receptor (MOR) and δ-opioid receptor (DOR). Aticaprant is under development for the treatment of major depressive disorder and substance use disorders including alcoholism, nicotine addiction, and illicit drug dependence. Aticaprant has been found to dose-dependently block fentanyl-induced miosis at 25 mg and 60 mg in humans (with minimal to no blockade at doses of 4 to 10 mg), indicating that the drug significantly occupies and antagonizes the MOR at a dose of at least 25 mg but not of 10 mg or less.