bs-6532C
[Life Science]
KI-20227
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 480.54
Formula: C24 H24 N4 O5 S
CAS Number: 623142-96-1
InChi Key: SHPFDGWALWEPGS-UHFFFAOYSA-N
InChi: InChI=1S/C24H24N4O5S/c1-14(23-26-9-10-34-23)27-24(29)28-17-6-5-15(11-20(17)30-2)33-19-7-8-25-18-13-22(32-4)21(31-3)12-16(18)19/h5-14H,1-4H3,(H2,27,28,29)
Smiles: COC1C=C2C(=CC=1OC)N=CC=C2OC1=CC(OC)=C(C=C1)NC(=O)NC(C)C1=NC=CS1
Purity: 98.0
Solubility: DMSO: 96 mg/mL(199.77 mM).
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C24 H24 N4 O5 S
CAS Number: 623142-96-1
InChi Key: SHPFDGWALWEPGS-UHFFFAOYSA-N
InChi: InChI=1S/C24H24N4O5S/c1-14(23-26-9-10-34-23)27-24(29)28-17-6-5-15(11-20(17)30-2)33-19-7-8-25-18-13-22(32-4)21(31-3)12-16(18)19/h5-14H,1-4H3,(H2,27,28,29)
Smiles: COC1C=C2C(=CC=1OC)N=CC=C2OC1=CC(OC)=C(C=C1)NC(=O)NC(C)C1=NC=CS1
Purity: 98.0
Solubility: DMSO: 96 mg/mL(199.77 mM).
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
KI-20227 is a potent and orally active inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R) (IC50 values are 2, 12, 217 and 451 nM for c-Fms, VEGFR-2, PDGFRβ and c-Kit respectively). KI-20227 suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. KI-20227 inhibits disease progression in a collagen-induced arthritis mouse model. KI-20227 suppresses experimental autoimmune encephalomyelitis.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.