bs-6524C

DATASHEET

Formulation Powder

Storage: Store in dry, dark place at -20C for 1 year.

Product Information:

Molecular Weight: 448.54

Formula: C22 H24 N8 O S

CAS Number: 1037792-44-1

InChi Key: NFTMKHWBOINJGM-UHFFFAOYSA-N

InChi: InChI=1S/C22H24N8OS/c1-2-16-11-23-22(24-12-16)29-9-7-17(8-10-29)21-26-18(14-32-21)13-31-20-5-3-19(4-6-20)30-15-25-27-28-30/h3-6,11-12,14-15,17H,2,7-10,13H2,1H3

Smiles: CCC1=CN=C(N=C1)N1CCC(CC1)C1=NC(COC2C=CC(=CC=2)N2C=NN=N2)=CS1

Purity: 98.0

Solubility: Soluble in DMSO

Appearance: Solid Power

Shelf Life: 1.0 years

Description:

MBX-2982, also known as SAR-260093, is a potential first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119 (GPR119), a receptor that interacts with bioactive lipids known to stimulate glucose-dependent insulin secretion. Preclinical data indicate that MBX-2982 is a potent selective orally-active GPR119 agonist that functions through a unique dual mechanism of action. First, it acts directly on the beta cell to increase insulin secretion. In addition, MBX-2982 stimulates release of the incretin GLP-1 from the gut. This dual action is unique and may offer improved glucose homeostasis over existing diabetes therapies, with potential for weight loss and improved islet health.